Molecular biophysics is about applying physical principles to the study of protein function, and we strive to deepen the scientific knowledge of what causes diseases and ultimately design novel therapeutics. In this research group, faculty, students and trainees investigate the link between structure and function. Through the application of chemistry, physics and mathematics, we study the function of biologically important proteins to develop a detailed understanding of how they work. The more we understand the structural basis of function, the better opportunities we have to understand what goes wrong in disease and develop methods of correction.
Using cutting-edge technology such as X-ray crystallography, nuclear magnetic resonance and cryotransmission electron microscopy, our researchers cover a broad range of interests with clinical implications, including:
- Alzheimer’s and other neurodegenerative diseases
- Anxiety disorders
- Autoimmune diseases
- Depression
- Gene expression
- Schizophrenia
With job opportunities in medicine, academia, government agencies and private industry, this research has far-reaching, real-world applicability for students and trainees beyond their time at VCU. For example, investigators in our department have been investigating the antidepressant effects of psychedelic drugs and related compounds.
Unlocking the mysteries and mechanisms behind psychedelics’ antidepressant activity
School of Medicine researchers are looking to understand the antidepressant effects of psychedelic drugs, with an eye toward developing non-hallucinogenic versions.
Partners and collaborators
Faculty
Carlos R. Escalante, Ph.D.
Professor and Graduate Program Director
Qinglian Liu, Ph.D.
Professor
I. Scott Ramsey, Ph.D.
Associate Professor
Montserrat Samso, Ph.D.
Associate Professor
Gea-Ny Tseng, Ph.D.
Professor
